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MDMA is a synthetic psychoactive compound currently being studied for its potential role in psychotherapy, particularly in the treatment of post-traumatic stress disorder (PTSD). Unlike traditional psychedelics, MDMA is classified as an empathogen, known for its effects on emotional processing, trust, and fear response. Modern research into MDMA focuses on controlled, medically supervised settings where safety, ethics, and therapeutic outcomes are rigorously evaluated. High Science® presents MDMA through a plant science and clinical research lens to help the public understand what the science shows, where research stands today, and how regulation shapes its future.
MDMA (3,4-methylenedioxymethamphetamine) is a synthetic psychoactive compound classified as an empathogen, distinct from classic psychedelics. (Jan 26′) NIH.gov
MDMA increases the release of serotonin, dopamine, and norepinephrine, with particularly strong effects on serotonin signaling related to mood and emotional processing. (Jan 26′) NIH.gov
Neuroimaging studies show MDMA reduces activity in the amygdala, a brain region involved in fear and threat processing. (Jan 26′) NIH.gov
Phase 3 clinical trials found MDMA-assisted therapy significantly reduced PTSD symptoms compared to placebo with psychotherapy alone. (Jan 26′) NEJM.org
MDMA-assisted therapy received FDA Breakthrough Therapy designation for PTSD, reflecting its potential over existing treatments. (Jan 26′) FDA.gov
In clinical trials, MDMA is administered in limited doses alongside structured psychotherapy sessions, not as a take-home medication. (Jan 26′) MAPS.org
Clinical protocols require cardiovascular screening due to MDMA’s effects on heart rate, blood pressure, and body temperature. (Jan 26′) NIH.org
Modern clinical trials report low rates of serious adverse events when MDMA is administered under medical supervision. (Jan 26′) ClinicalTrials.org
MDMA is classified as a Schedule I substance under U.S. federal law and is illegal outside approved research settings. (Jan 26′) USDOJ.gov
MDMA research is conducted internationally, including by academic institutions and nonprofit research organizations focused on trauma treatment. (Jan 26′) NIH.gov
Disclaimer: The information provided on High Science is for educational purposes only and is not intended as medical advice. Cannabis affects individuals differently, and laws vary by location. Always consult with a licensed healthcare professional before making decisions about cannabis use, especially if you have medical conditions, are pregnant, nursing, or taking medications. All information presented is for educational purposes only and focuses on plant science research and emerging studies. This content does not replace professional medical advice. Always consult licensed healthcare providers or trained professionals in plant-based science and natural health disciplines. All information provided is thought to be put to date with modern research and you should still do your own research and consult with professionals.
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