Ashwagandha is generally considered well tolerated in healthy adults when consumed within clinically studied dosage ranges. Most human trials report few adverse effects, and those observed are typically mild and transient. Commonly reported side effects include gastrointestinal discomfort, such as nausea, stomach upset, or diarrhea, particularly when taken on an empty stomach or at higher doses. National Center for Complementary and Integrative Health (NCCIH)
Central nervous system–related effects such as drowsiness or sedation have been reported in some individuals. These effects are usually mild and may be more noticeable when ashwagandha is combined with other substances that have calming or sedative properties. Clinical literature notes that ashwagandha does not impair cognition or motor coordination in controlled settings, distinguishing it from sedative medications. National Institutes of Health – Office of Dietary Supplements
Rare cases of more serious adverse reactions have been documented, including liver injury temporally associated with ashwagandha use. While these cases are uncommon and causality is not always clear, medical reviews emphasize the importance of product quality, appropriate dosing, and monitoring for symptoms such as jaundice or unexplained fatigue. National Institutes of Health – LiverTox Database
Ashwagandha may also influence thyroid hormone levels. Some studies suggest it can increase circulating thyroid hormones, which may be beneficial for certain individuals but problematic for those with hyperthyroidism or those taking thyroid hormone replacement. Medical guidance recommends caution and monitoring in individuals with known thyroid conditions. National Center for Biotechnology Information (NCBI)
Overall tolerability of ashwagandha appears favorable when used responsibly and under appropriate guidance. Researchers and health authorities consistently emphasize that natural origin does not guarantee safety, reinforcing the need for informed use, attention to individual health status, and consultation with healthcare professionals when uncertainty exists. World Health Organization (WHO)
All information presented is for educational purposes only and focuses on plant science research and emerging studies. This content does not replace professional medical advice. Always consult licensed healthcare providers or trained professionals in plant-based science and natural health disciplines. All information provided is thought to be put to date with modern research and you should still do your own research and consult with professionals.
