Nabiximols, marketed under the brand name Sativex, is a pioneering cannabis-based medication developed by GW Pharmaceuticals in the United Kingdom. It is an oromucosal spray designed to alleviate symptoms associated with multiple sclerosis (MS), including neuropathic pain, spasticity, and overactive bladder.
Composition and Administration
Nabiximols is a standardized combination of two primary cannabinoids:
• Tetrahydrocannabinol (THC): Each spray delivers 2.7 mg of THC.
• Cannabidiol (CBD): Each spray provides 2.5 mg of CBD.
The medication is administered as a mouth spray, allowing for flexible dosing tailored to individual patient needs.
Medical Applications
Initially approved in the UK in 2010, Nabiximols has been utilized to manage:
• Spasticity in Multiple Sclerosis: Clinical trials have demonstrated its efficacy in reducing muscle stiffness and improving mobility in MS patients.
• Neuropathic Pain: It has shown effectiveness in alleviating nerve pain associated with MS.
• Overactive Bladder: Nabiximols may help in reducing urinary urgency and frequency in MS patients.
Global Availability
Beyond the UK, Nabiximols has received approval in several countries for treating MS-related symptoms. In 2011, GW Pharmaceuticals partnered with Novartis to commercialize the drug in regions including Asia (excluding China and Japan), Africa, and the Middle East (excluding Israel).
Side Effects and Tolerability
Clinical trials indicate that Nabiximols is generally well-tolerated. Common side effects include dizziness, drowsiness, and disorientation. Approximately 12% of participants discontinued use due to adverse effects. Notably, there is no substantial evidence suggesting a negative impact on cognitive abilities.
Conclusion
Nabiximols represents a significant advancement in the integration of cannabis-based compounds into modern medicine. Its development and approval have paved the way for further research into the therapeutic potential of cannabinoids, offering hope and relief to patients with conditions like multiple sclerosis.
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Source of Information: Wikipedia
