New research reveals that psilocybin—the main active ingredient in psychedelic mushrooms—could play a powerful role in helping people recover from traumatic brain injury (TBI). A scientific review by medical experts found that psilocybin may reduce inflammation, support brain cell regrowth, and help heal emotional damage following brain trauma.
The researchers evaluated nearly 30 previous studies, uncovering consistent evidence that psilocybin may encourage key healing processes. It appears to ease swelling in the brain, spark the growth of new neural pathways, and aid recovery after injury. It also might help with depression—a common side effect in TBI patients.
Brain injuries often trigger conditions like anxiety, depression, and cognitive challenges. Right now, patients have limited treatment options. The findings suggest that psilocybin therapy may one day offer a meaningful way to tackle both the physical and emotional aftermath of TBI.
However, the scientists are also cautious. They point out the need for large-scale clinical trials to test safety, proper dosing, and long-term effects. Because psilocybin remains a Schedule I controlled substance, it’s hard for researchers to run the kind of studies that could bring this therapy to the clinic.
If future trials confirm its benefits, psilocybin could mark a major breakthrough—not just for TBI, but for how we understand compassionate, plant-based healing using THC, CBD, hemp, and psychedelics.
At High Science, we believe in progress grounded in evidence. Whether it’s through cannabis clothing or honest conversation, we’re here to support healing, safety, and evolution in cannabis and natural medicine.
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